Closing the Men’s Health Gap with AI and Precision Medicine

From digital clinics to personalized diagnostics, healthcare innovations that are finally meeting men where they are

In the United States, men die nearly five years sooner than women. In 2024, male life expectancy reached 76.5 years, compared to 81.4 for women, according to the latest CDC data. That gap has nearly tripled over the past century, and it’s not because of biology alone. Men are less likely to visit a doctor, less likely to seek mental health support, and more likely to delay treatment until conditions become severe.

AI in men’s health is starting to change that equation. Across digital clinics, at-home diagnostics, surgical suites, and mental health platforms, a new generation of AI-powered tools is reaching men who would otherwise fall through the cracks. These aren’t abstract research projects. They’re live platforms treating real patients, backed by clinical evidence, and scaling fast.

This is what precision medicine for men looks like in 2026: personalized, private, accessible, and increasingly difficult to ignore.

Digital Clinics for Men’s Health: How Platforms Like Fellos Are Removing Barriers to Care

The Amsterdam-based startup Fellos has grown from a 2024 launch to more than 10,000 patients treated through a fully digital model. The platform focuses on conditions where men face the highest barriers to seeking help: sexual health (erectile dysfunction, premature ejaculation), skin conditions like acne, and hair loss.

The process is simple. Men connect with licensed physicians through confidential chat consultations. If medication is prescribed, it ships discreetly through partner pharmacies. No waiting room. No awkward conversation with a receptionist.

Fellos raised €2.15 million in growth capital in 2025, with investors citing the sheer scale of unmet demand. Research consistently shows that 40–60% of men experiencing erectile dysfunction never seek medical attention or take medication under professional guidance. That silence leads to cascading problems: misdiagnosis, drug misuse, and untreated underlying conditions (heart disease, diabetes) that often first show up as sexual dysfunction.

Fellos isn’t alone in this space. The UK-based Numan raised €51.6 million to scale its preventive healthcare model. Switzerland’s Comphya secured €8 million for an implantable device treating erectile dysfunction. Across Europe, digital men’s health is attracting serious investment because the demand has always been there. The access hasn’t.

And the digital health shift extends beyond sexual health. Extended reality technologies, including augmented and virtual reality, are transforming remote medical consultations. In specialized pilot programs now underway, surgeons are performing complex procedures using haptic-feedback robotic systems controlled remotely, while patients receive consultations through immersive virtual environments. For men in rural or underserved areas who might otherwise travel hundreds of miles for specialist care, these tools are a genuine lifeline.

AI and Prostate Cancer: From Predictive Models to Nerve-Sparing Surgery

Prostate cancer is the second-leading cause of cancer death among American men and the most commonly diagnosed cancer among men in Europe and Australia. Incidence rates are climbing sharply across Asia. Any technology that improves treatment outcomes here has massive reach.

AI is making a measurable difference at both ends of the treatment pipeline.

On the diagnostic side, recent studies analyzing cohorts of more than 8,500 patients have produced machine learning models that predict urinary continence and erectile function recovery following robotic-assisted prostatectomy. These neural network models assess postoperative outcomes with a level of accuracy that traditional risk tools simply couldn’t match, helping both surgeons and patients make better-informed treatment decisions.

On the surgical side, the NeuroSAFE technique has produced the most compelling clinical evidence to date. Published in The Lancet Oncology in 2025 and presented at the European Association of Urology Congress in Madrid, the NeuroSAFE PROOF trial (a multicentre, randomized, controlled phase 3 study across five UK hospitals) evaluated a method of preserving the nerves responsible for erections during prostate removal.

The results were significant. Twelve months after surgery, 39% of men in the NeuroSAFE group reported no or mild erectile dysfunction, compared to 23% with standard surgery. Severe erectile dysfunction affected 38% of the NeuroSAFE group versus 56% of those who had conventional procedures. The technique did not compromise cancer control.

Professor Greg Shaw, the trial lead from UCL, summarized it directly: NeuroSAFE allows nearly twice as many men to avoid potentially life-changing loss of erectile function after prostate surgery, without jeopardizing cancer removal.

Research activity in AI applications for sexual health has surged since 2020. Investigators are now exploring everything from diagnosis through advanced imaging and wearable sensors to predictive modeling and drug discovery. For men facing prostate cancer treatment, these advances represent a measurable improvement in post-treatment quality of life.

At-Home Health Testing for Men: How MNLY Uses AI and Biomarker Data

The platform MNLY shows what becomes possible when AI, at-home blood testing, and personalized supplementation work together as a single system.

Launched in 2021, MNLY analyzes approximately 100 distinct data points per user. These come from two sources: 19 blood biomarkers collected via an at-home finger-prick kit, and an 86-question health assessment covering concentration, confidence, stamina, mood, sleep, libido, and recovery.

The AI engine processes this combined dataset and delivers results within 48 hours of the lab receiving samples. That’s significantly faster than traditional telehealth providers, where practitioner bottlenecks often push wait times to 60–90 days for lab interpretation and treatment plans. The system generates personalized nutrition plans, evidence-based lifestyle recommendations, and custom-formulated supplements that are manufactured and shipped monthly.

As users retest every three to five months, the AI adjusts supplement dosages and health recommendations based on evolving biomarkers. Early results from beta programs consistently uncovered significant hormone, vitamin, and nutrient deficiencies in most male participants. These are deficiencies that often go undetected in standard annual physicals because conventional testing checks only a fraction of what’s relevant.

This precision approach reflects broader trends in AI-driven hormone monitoring throughout 2025 and 2026. Continuous tracking technology now provides real-time data on hormone levels, helping identify personal patterns rather than relying on single-point-in-time snapshots. Physicians can make decisions based on each patient’s unique biological rhythms instead of population averages that may not apply to individual cases.

AI-Powered Mental Health Tools Built for How Men Actually Seek Help

Prince Harry’s decade of advocacy with veterans and mental health organizations has exposed a pattern that goes well beyond military service. Men across all communities experience profound isolation rooted in a shared but unspoken assumption: that no one else will truly understand what they’re going through.

Research confirms the disconnect. Men dramatically underestimate how many of their peers support open emotional conversations. That perception gap keeps millions from seeking help they’d readily accept if they knew others felt the same way.

AI-powered mental health tools are well suited to this problem because they match how many men actually approach getting help. They offer privacy: confidential digital spaces where men can express concerns without fear of judgment from colleagues, family, or friends. They offer round-the-clock accessibility, which accommodates demanding work schedules and removes geographical barriers. And the digital interface creates enough emotional distance that many men find it easier to take that first step toward acknowledging their struggles.

Current AI applications in men’s mental health span a wide range. Early detection systems use natural language processing to identify subtle linguistic markers of depression, anxiety, or suicidal ideation in text communications. Personalized digital companions deliver cognitive behavioral therapy techniques adapted to men’s specific communication styles. Virtual reality exposure therapy allows men to confront stressful situations or process trauma in controlled environments, building resilience and healthier coping patterns over time.

In the UK, the government recently committed £3.6 million in funding for 17 projects using extended reality technology for mental health support. Smart glasses are central to several of these initiatives. CrossSense, a London-based company, has developed lightweight smart glasses that use AI to help people with severe depression complete everyday tasks, providing real-time, context-aware prompts through a discreet wearable interface.

Prince Harry has also been vocal about social media’s role in the crisis, arguing that too many young men are being shaped by algorithms designed to maximize engagement through outrage rather than by real mentors who model emotional honesty. Changing platform incentive structures to reward genuine connection over exploitation could shift how an entire generation of boys understands strength and vulnerability.

What Comes Next: The Future of AI in Men’s Health

The platforms and clinical advances profiled here are early movers in a much larger shift. Several trends will define the next three to five years.

Device costs will continue to fall. As at-home testing kits, wearable biosensors, and AI diagnostic tools reach larger markets, pricing will drop to consumer-friendly levels. MNLY’s model of AI-driven analysis paired with monthly subscription supplements is likely to be replicated across multiple health categories.

Clinical evidence will accumulate. The NeuroSAFE PROOF trial set a new standard for rigorous evaluation of surgical innovation. Expect similar randomized controlled trials for AI-assisted diagnostics, digital therapeutics, and remote monitoring tools targeting men’s health conditions.

Integration will deepen. Wearable data from devices like Oura Ring, WHOOP, and continuous glucose monitors will feed into AI systems that create truly comprehensive health profiles. The silos between fitness tracking, blood work, mental health monitoring, and clinical care will start to dissolve.

Mental health tools will mature. AI-powered companions and early detection systems will move from pilot programs to mainstream adoption, driven by growing clinical validation and expanding insurance coverage for digital therapeutics.

The transformation won’t happen all at once. Healthcare moves carefully, and it should. But the direction is clear. As clinical evidence builds, costs fall, and regulatory frameworks catch up, AI in men’s health will move from innovative to expected. The men who’ve been hardest to reach will finally have tools built to meet them where they are.

FAQ: AI and Men’s Health

How is AI being used in men’s health?

AI is being used across several areas of men’s health: digital clinics like Fellos use AI-driven consultations to treat sexual health conditions, skin conditions, and hair loss. Platforms like MNLY use AI to analyze blood biomarkers and generate personalized supplement and nutrition plans. In prostate cancer surgery, AI-based predictive models help surgeons and patients make better-informed treatment decisions. And AI-powered mental health tools use natural language processing to detect early signs of depression and deliver cognitive behavioral therapy techniques adapted for men.

What is NeuroSAFE prostate surgery?

NeuroSAFE is a surgical technique used during robot-assisted prostate removal that preserves the nerves responsible for erectile function. During the operation, the prostate is flash-frozen and examined by a pathologist in real time. If cancer is found at the nerve margins, the surgeon removes additional tissue. If the margins are clear, the nerves are preserved. The NeuroSAFE PROOF trial, published in The Lancet Oncology in 2025, showed that 39% of men had no or mild erectile dysfunction 12 months after surgery, compared to 23% with standard procedures.

Why do men avoid going to the doctor?

Multiple factors contribute to men’s lower rates of healthcare engagement. These include stigma around vulnerability, cultural expectations of self-reliance, embarrassment about specific conditions (particularly sexual health), time constraints from work, and a general tendency to minimize symptoms. Research shows that 40–60% of men with erectile dysfunction never seek professional help, and men across all demographics underestimate how many of their peers support open conversations about health.

What are the best digital health platforms for men in 2026?

Several platforms are leading the digital men’s health space. Fellos (Netherlands) provides confidential online consultations for sexual health, skin conditions, and hair loss. MNLY (US) offers AI-driven biomarker analysis with personalized supplements. Numan (UK) provides preventive healthcare services. Fella Health (US) specializes in GLP-1 weight management and testosterone support. CrossSense (UK) is developing AI-powered smart glasses for mental health support. The right platform depends on the specific health need and geographic availability.

Is AI-powered health testing accurate?

AI-powered health testing is increasingly accurate when paired with validated biomarker analysis and clinical oversight. Platforms like MNLY process results through AI models trained on evidence-based protocols and overseen by scientific advisory boards. The AI in prostate cancer treatment has been validated in large clinical trials involving thousands of patients. That said, AI health tools work best as complements to professional medical care, not replacements for it. Users should always consult a physician for clinical decisions.

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